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Mathis, C., Denisenko-Nehrbass, N., Girault, J. A. \n& Borrelli, E. Essentia\ l role of oligodendrocytes in the formation and maintenance of central nervous system nodal regions. Development 128, 4881 \ 4890 \(2001\).\r:119)/F 4/H/N/Rect[158.591 147.855 163.851 135.444]/Subtype/Link/Type/Annot>> endobj 4 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:20. Vabnick, I. etal. Sodium channel distribution in \naxons of hypomyelinated \ and MAG null mutant mice. J. Neurosci. Res. 50, 321 336 \(1997\).\r:120)/F 4/H/N/Rect[165.13 147.855 170.39 135.444]/Subtype/Link/Type/Annot>> endobj 5 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:21. Dugandzija-Novakovic, S., Koszowski, A. G., \nLevinson, S. R. & Shrager, P. \ Clustering of \nNa+ channels and node of Ranvier formation in remyelinating axons. J. Neurosci. 15, 492 503 \(1995\).\r:121)/F 4/H/N/Rect[257.109 147.855 262.37 135.444]/Subtype/Link/Type/Annot>> endobj 6 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:23. Arroyo, E. J., Sirkowski, E. E., Chitale, R. & Scherer, S. S. Acute demyeli\ nation disrupts the molecular organization of peripheral nervous system nodes. \nJ. Comp. Neurol. 479, 424 434 \(2004\).\r:12\ 2)/F 4/H/N/Rect[265.214 147.855 270.475 135.444]/Subtype/Link/Type/Annot>> endobj 7 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:24. Kaplan, M. R. etal. Induction of sodium channel clustering by oligodendroc\ ytes. Nature 386, \n724 728 \(1997\).\r:123)/F 4/H/N/Rect[240.848 103.855 246.118 91.4439]/Subtype/Link/Type/Annot>> endobj 8 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:25. Freeman, S. A. etal. Acceleration of conduction velocity linked to cluster\ ing of nodal components precedes myelination. Proc. Natl Acad. Sci. USA \n112, E321 E328 \(2015\).\r:124)/F 4/H/N/Rect[330.096 103.855 335.366 91.4439]/Subtype/Link/Type/Annot>> endobj 9 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:26. Dubessy, A. L. etal. Role of a contactin multi-\nmolecular complex secreted\ by oligodendrocytes \nin nodal protein clustering in the CNS. Glia 67, 2248 2263 \(2019\).\r:125)/F 4/H/N/Rect[336.649 103.855 341.858 91.4439]/Subtype/Link/Type/Annot>> endobj 10 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:27. Thetiot, M. etal. An alternative mechanism of early nodal clustering and m\ yelination onset in GABAergic neurons of the central nervous system. Glia 68, 1891 1909 \(2020\).\r:126)/F 4/H/N/Rect[381.404 180.855 386.691 168.444]/Subtype/Link/Type/Annot>> endobj 11 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:28. Rosenbluth, J. Multiple functions of the paranodal junction of myelinated n\ erve fibers. J. Neurosci. 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Electron microscopic serial section analysis \ of nodes of Ranvier in lumbosacral spinal roots of the cat: ultrastructural organization of nodal compartments in fibres of diff\ erent sizes. J. Neurocytol. 12, 475 :129)/F 4/H/N/Rect[196.771 378.855 201.927 366.444]/Subtype/Link/Type/Annot>> endobj 264 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:30. Butt, A. M., Duncan, A. & Berry, M. Astrocyte associations with nodes of Ra\ nvier: ultrastructural analysis of HRP-filled astrocytes in the mouse optic nerve. J. Neurocytol. 23, 486 499 \(1994\).\r:13\ 0)/F 4/H/N/Rect[257.402 345.855 262.766 333.444]/Subtype/Link/Type/Annot>> endobj 265 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:32. Serwanski, D. R., Jukkola, P. & Nishiyama, A. Heterogeneity of astrocyte a\ nd NG2 cell insertion at the node of Ranvier. J. Comp. Neurol. 525, 535 552 \(2017\).\r:131)/F 4/H/N/Rect[265.663 345.855 271.028 333.444]/Subtype/Link/Type/Annot>> endobj 266 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Fig. 1 | Organization of the nodal environ. a | Myelin formed by Sc\ hwann cells or \noligodendrocytes \(not shown\) covers the axon in segments \(internodes\) separated by \nthe nodes of Ranvier. The\ nodes of Ranvier, which are flanked by the:132)/F 4/H/N/Rect[291.585 345.855 300.576 333.444]/Subtype/Link/Type/Annot>> endobj 267 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:33. Ffrench-Constant, C., Miller, R. H., Kruse, J., Schachner, M. & Raff, M. C.\ Molecular specialization of astrocyte processes at nodes of Ranvier in rat optic nerve. J. Cell Biol. 102, 844 852 \(1986\).\ \r:133)/F 4/H/N/Rect[197.393 323.855 202.633 311.444]/Subtype/Link/Type/Annot>> endobj 268 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:34. Davis, J. Q., Lambert, S. & Bennett, V. Molecular composition of the node\ of Ranvier: identification of ankyrin-binding cell adhesion molecules neurofascin \(mucin+/third FNIII domain-\) and NrCAM at no\ dal axon segments. J. Cell Biol. 135,:134)/F 4/H/N/Rect[223.701 202.855 228.922 190.444]/Subtype/Link/Type/Annot>> endobj 269 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:35. Kordeli, E., Lambert, S. & Bennett, V. AnkyrinG. A new ankyrin gene with n\ eural-specific isoforms localized \nat the axonal initial segment and node of Ranvier. \nJ. Biol. Chem. 270, 2352 2359 \(1995\ \).\r:135)/F 4/H/N/Rect[233.707 191.855 239.13 179.444]/Subtype/Link/Type/Annot>> endobj 270 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Fig. 1 | Organization of the nodal environ. a | Myelin formed by S\ chwann cells or \noligodendrocytes \(not shown\) covers the axon in segments \(internodes\) separated by \nthe nodes of Ranvier. Th\ e nodes of Ranvier, which are flanked by th:136)/F 4/H/N/Rect[260.257 191.855 268.557 179.444]/Subtype/Link/Type/Annot>> endobj 271 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:36. Lambert, S., Davis, J. Q. & Bennett, V. Morphogenesis of the node of Ranvie\ r: co-clusters of ankyrin and ankyrin-binding integral proteins define early developmental intermediates. J. Neurosci. 17, \n\ 7025 7036 \(1997\).\r:137)/F 4/H/N/Rect[257.968 136.855 263.148 124.444]/Subtype/Link/Type/Annot>> endobj 272 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:17. Schafer, D. P., Custer, A. W., Shrager, P. & \nRasband, M. N. Early events \ in node of Ranvier formation during myelination and remyelination \nin the PNS. Neuron Glia Biol. 2, 69 79 \(2006\).\r:138)/F 4/H/N/Rect[209.903 103.855 214.951 91.4439]/Subtype/Link/Type/Annot>> endobj 273 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:37. Eshed, Y. etal. Gliomedin mediates schwann cell-axon interaction and the \ molecular assembly of the nodes of ranvier. Neuron 47, 215 229 \(2005\). \nThis paper shows that gliomedin is the Schwann ce\ ll-derived factor that interacts with axon:139)/F 4/H/N/Rect[216.122 103.855 221.17 91.4439]/Subtype/Link/Type/Annot>> endobj 274 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:39. Susuki, K. etal. Three mechanisms assemble central nervous system nodes \ of Ranvier. Neuron 78, \n469 482 \(2013\). \nThis paper reveals perinodal NF186-interacting ECM molecules that function as a \ secondary mechanism after paranodal juncti:140)/F 4/H/N/Rect[223.908 103.855 228.955 91.4439]/Subtype/Link/Type/Annot>> endobj 275 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:40. Sherman, D. L. etal. Neurofascins are required to establish axonal domains\ for saltatory conduction. Neuron 48, 737 742 \(2005\). \nThis paper shows that neurofascins are required for node of Ranvie\ r formation.\r:141)/F 4/H/N/Rect[442.792 719.855 448.232 707.444]/Subtype/Link/Type/Annot>> endobj 276 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:41. Tait, S. etal. An oligodendrocyte cell adhesion molecule at the site of as\ sembly of the paranodal axo-glial junction. J. Cell Biol. 150, 657 666 \(2000\).\r:142)/F 4/H/N/Rect[442.494 653.855 447.655 641.444]/Subtype/Link/Type/Annot>> endobj 277 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:42. Pillai, A. M. etal. Spatiotemporal ablation of myelinating glia-specific n\ eurofascin \(Nfasc NF155\) \nin mice reveals gradual loss of paranodal axoglial junctions and concomitant disorganization of axon\ al domains. J. Neurosci. Res. 87, 1773:143)/F 4/H/N/Rect[448.884 653.855 454.045 641.444]/Subtype/Link/Type/Annot>> endobj 278 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Box 1 | Involvement of nodal environ components in human diseases\rThe importanc\ e of the nodes of Ranvier to the normal function of the nervous system \nis reinforced by the involvement of different nodal as \ well as paranodal components \nin neurolog:144)/F 4/H/N/Rect[430.635 587.855 435.045 575.444]/Subtype/Link/Type/Annot>> endobj 279 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:43. Zonta, B. etal. Glial and neuronal isoforms of neurofascin have distinct r\ oles in the assembly \nof nodes of Ranvier in the central nervous system. \nJ. Cell Biol. 181, 1169 1177 \(2008\). \nThis pap\ er shows that neuronal or glial neurofascin:145)/F 4/H/N/Rect[423.374 565.855 428.579 553.444]/Subtype/Link/Type/Annot>> endobj 280 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:38. Feinberg, K. etal. A glial signal consisting of gliomedin and NrCAM clus\ ters axonal Na+ channels during the formation of nodes of Ranvier. Neuron 65, 490 502 \(2010\). \nThis paper shows that gl\ iomedin and NrCAM function as the primary :146)/F 4/H/N/Rect[510.658 466.855 515.884 454.444]/Subtype/Link/Type/Annot>> endobj 281 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:42. Pillai, A. M. etal. Spatiotemporal ablation of myelinating glia-specific \ neurofascin \(Nfasc NF155\) \nin mice reveals gradual loss of paranodal axoglial junctions and concomitant disorganization of axo\ nal domains. J. Neurosci. Res. 87, 177:147)/F 4/H/N/Rect[473.941 323.855 479.053 311.444]/Subtype/Link/Type/Annot>> endobj 282 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:44. Bhat, M. A. etal. Axon-glia interactions and the domain organization of my\ elinated axons requires neurexin IV/Caspr/Paranodin. Neuron 30, 369 383 \(2001\).\r:148)/F 4/H/N/Rect[537.996 290.855 542.975 278.444]/Subtype/Link/Type/Annot>> endobj 283 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:46. Poliak, S. etal. Localization of Caspr2 in myelinated nerves depends on ax\ on-glia interactions and the generation of barriers along the axon. J. Neurosci. \n21, 7568 7575 \(2001\).\r:149)/F 4/H/N/Rect[545.679 290.855 550.658 278.444]/Subtype/Link/Type/Annot>> endobj 284 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:47. Thaxton, C., Pillai, A. M., Pribisko, A. L., Dupree, J. L. & Bhat, M. A. No\ des of Ranvier act as barriers to restrict invasion of flanking paranodal domains in myelinated axons. Neuron 69, 244 257 \(\ 2011\).\r:150)/F 4/H/N/Rect[434.329 257.855 439.414 245.444]/Subtype/Link/Type/Annot>> endobj 285 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:48. Amor, V. etal. The paranodal cytoskeleton clusters Na+ channels at nodes\ of Ranvier. eLife 6, e21392 \(2017\). \nThis paper shows that, in the absence of NF186, the paranodal 2 spectrin-dependent\ cytoskeleton clusters nodal Na+ cha:151)/F 4/H/N/Rect[471.92 180.855 477.271 168.444]/Subtype/Link/Type/Annot>> endobj 286 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:7. Caldwell, J. H., Schaller, K. L., Lasher, R. S., Peles, E. \n& Levinson, S. R\ . Sodium channel Na\(v\)1.6 is \nlocalized at nodes of Ranvier, dendrites, and \nsynapses. Proc. Natl Acad. Sci. USA 97, 5616 \ 5620 \(2000\).\r:53)/F 4/H/N/Rect[323.953 590.13 326.416 580.61]/Subtype/Link/Type/Annot>> endobj 287 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:8. Kanda, H. etal. TREK-1 and TRAAK are principal \nK+ channels at the nodes \ of Ranvier for rapid action potential conduction on mammalian myelinated afferent nerves. Neuron 104, 960 971.e7 \(2019\). \n\ This paper reveals the long-sought for le:54)/F 4/H/N/Rect[235.154 580.13 237.617 570.61]/Subtype/Link/Type/Annot>> endobj 288 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:9. Brohawn, S. G. etal. The mechanosensitive ion channel TRAAK is localized to\ the mammalian node \nof Ranvier. eLife 8, e50403 \(2019\).\r:55)/F 4/H/N/Rect[238.588 580.13 241.051 570.61]/Subtype/Link/Type/Annot>> endobj 289 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:11. Devaux, J. J., Kleopa, K. A., Cooper, E. C. & \nScherer, S. S. KCNQ2 is a no\ dal K+ channel. J. Neurosci. 24, 1236 1244 \(2004\).\r:56)/F 4/H/N/Rect[242.022 580.13 246.948 570.61]/Subtype/Link/Type/Annot>> endobj 290 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:12. Devaux, J. etal. Kv3.1b is a novel component \nof CNS nodes. J. Neurosci.\ 23, 4509 4518 \n\(2003\).\r:57)/F 4/H/N/Rect[247.919 580.13 252.845 570.61]/Subtype/Link/Type/Annot>> endobj 291 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:38. Feinberg, K. etal. A glial signal consisting of gliomedin and NrCAM cluste\ rs axonal Na+ channels during the formation of nodes of Ranvier. Neuron 65, 490 502 \(2010\). \nThis paper shows that glio\ medin and NrCAM function as the primary me:58)/F 4/H/N/Rect[126.944 530.87 131.87 519.403]/Subtype/Link/Type/Annot>> endobj 292 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:66. Colombelli, C. etal. Perlecan is recruited by dystroglycan to nodes of Ran\ vier and binds the clustering molecule gliomedin. J. Cell Biol. 208, \n313 329 \(2015\).\r:59)/F 4/H/N/Rect[231.921 530.87 236.847 519.403]/Subtype/Link/Type/Annot>> endobj 293 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:68. Melendez-Vasquez, C. etal. Differential expression \nof proteoglycans at ce\ ntral and peripheral nodes of Ranvier. Glia 52, 301 308 \(2005\).\r:60)/F 4/H/N/Rect[60.5444 520.13 65.4702 510.61]/Subtype/Link/Type/Annot>> endobj 294 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:69. Goutebroze, L., Carnaud, M., Denisenko, N., Boutterin, M. C. & Girault, J. \ A. Syndecan-3 and syndecan-4 are enriched in Schwann cell perinodal processes. BMC Neurosci. 4, 29 \(2003\).\r:61)/F 4/H/N/Rect[66.4414 520.13 71.3671 510.61]/Subtype/Link/Type/Annot>> endobj 295 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:136. Bang, M. L. etal. Glial M6B stabilizes the axonal membrane at peripheral \ nodes of Ranvier. Glia 66, 801 812 \(2018\).\r:62)/F 4/H/N/Rect[106.412 520.13 113.8 510.61]/Subtype/Link/Type/Annot>> endobj 296 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:39. Susuki, K. etal. Three mechanisms assemble central nervous system nodes of\ Ranvier. Neuron 78, \n469 482 \(2013\). \nThis paper reveals perinodal NF186-interacting ECM molecules that function as a se\ condary mechanism after paranodal junction:63)/F 4/H/N/Rect[164.114 470.13 169.039 460.61]/Subtype/Link/Type/Annot>> endobj 297 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:71. Bekku, Y., Rauch, U., Ninomiya, Y. & Oohashi, T. Brevican distinctively ass\ embles extracellular components at the large diameter nodes of Ranvier \nin the CNS. J. Neurochem. 108, 1266 1276 \(2009\).\r\ :64)/F 4/H/N/Rect[170.011 470.13 174.936 460.61]/Subtype/Link/Type/Annot>> endobj 298 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:73. Oohashi, T. etal. Bral1, a brain-specific link protein, colocalizing with \ the versican V2 isoform at the nodes of Ranvier in developing and adult mouse central nervous systems. Mol. Cell Neurosci. 19\ , 43 57 \(2002\).\r:65)/F 4/H/N/Rect[175.908 470.13 180.833 460.61]/Subtype/Link/Type/Annot>> endobj 299 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:121. Chang, K. J. etal. Glial ankyrins facilitate paranodal axoglial junction \ assembly. Nat. Neurosci. 17, \n1673 1681 \(2014\).\r:66)/F 4/H/N/Rect[236.247 420.13 243.636 410.61]/Subtype/Link/Type/Annot>> endobj 300 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:112. Poliak, S. & Peles, E. The local differentiation of myelinated axons at no\ des of Ranvier. Nat. Rev. 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Desmazieres, A. etal. Differential stability of PNS and CNS nodal complexe\ s when neuronal neurofascin is lost. J. Neurosci. 34, 5083 5088 \(2014\).\r:152)/F 4/H/N/Rect[314.872 202.855 319.953 190.444]/Subtype/Link/Type/Annot>> endobj 308 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Box 1 | Involvement of nodal environ components in human diseases\rThe importan\ ce of the nodes of Ranvier to the normal function of the nervous system \nis reinforced by the involvement of different nodal as\ well as paranodal components \nin neurolo:153)/F 4/H/N/Rect[254.945 147.855 259.465 135.444]/Subtype/Link/Type/Annot>> endobj 309 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:50. Custer, A. W. etal. The role of the ankyrin-binding protein NrCAM in node \ of Ranvier formation. \nJ. 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Neuron 47, 215 229 \(2005\). \nThis paper shows that gliomedin is the Schwann c\ ell-derived factor that interacts with axo:156)/F 4/H/N/Rect[532.137 719.855 537.232 707.444]/Subtype/Link/Type/Annot>> endobj 312 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:52. Davis, J. Q. & Bennett, V. Ankyrin binding activity shared by the neurofasc\ in/L1/NrCAM family of nervous system cell adhesion molecules. J. Biol. Chem. 269, 27163 27166 \(1994\).\r:157)/F 4/H/N/Rect[398.886 708.855 404.13 696.444]/Subtype/Link/Type/Annot>> endobj 313 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:38. Feinberg, K. etal. A glial signal consisting of gliomedin and NrCAM clu\ sters axonal Na+ channels during the formation of nodes of Ranvier. 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Neurosci. 37, 11323 1133\ 4 \(2017\).\r:107)/F 4/H/N/Rect[84.3307 303.25 91.7936 291.784]/Subtype/Link/Type/Annot>> endobj 356 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:144. Melendez-Vasquez, C. V. etal. Nodes of Ranvier form in association with e\ zrin-radixin-moesin \(ERM\)-positive Schwann cell processes. Proc. Natl Acad. Sci. USA 98, 1235 1240 \(2001\).\r:108)/F 4/H/N/Rect[92.0485 288.612 99.437 279.092]/Subtype/Link/Type/Annot>> endobj 357 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:145. Scherer, S. S., Xu, T., Crino, P., Arroyo, E. J. & Gutmann, D. H. Ezrin, r\ adixin, and moesin are components of Schwann cell microvilli. J. Neurosci. Res. 65, 150 164 \(2001\).\r:109)/F 4/H/N/Rect[100.408 288.612 107.871 279.092]/Subtype/Link/Type/Annot>> endobj 358 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:146. Song, G. J. etal. Loss-of-function of EBP50 is a new cause of hereditary \ peripheral neuropathy: EBP50 functions in peripheral nerve system. Glia 68, \n1794 1809 \(2020\).\r:110)/F 4/H/N/Rect[87.7361 274.714 95.1246 265.194]/Subtype/Link/Type/Annot>> endobj 359 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:147. Gatto, C. L., Walker, B. J. & Lambert, S. Local ERM activation and dynamic\ growth cones at Schwann \ncell tips implicated in efficient formation of nodes \nof Ranvier. J. Cell Biol. 162, 489 498 \(20\ 03\).\r:111)/F 4/H/N/Rect[96.0959 274.714 103.484 265.194]/Subtype/Link/Type/Annot>> endobj 360 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:141. Occhi, S. etal. Both laminin and Schwann cell dystroglycan are necessary\ for proper clustering \nof sodium channels at nodes of Ranvier. J. 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Ching, W., Zanazzi, G., Levinson, S. R. & Salzer, J. L. Clustering of neuro\ nal sodium channels requires contact with myelinating Schwann cells. J. Neurocytol. 28, 295 301 \(1999\).\r:198)/F 4/H/N/Rect[327.584 642.855 332.996 630.444]/Subtype/Link/Type/Annot>> endobj 370 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:17. Schafer, D. P., Custer, A. W., Shrager, P. & \nRasband, M. N. Early events\ in node of Ranvier formation during myelination and remyelination \nin the PNS. Neuron Glia Biol. 2, 69 79 \(2006\).\r:199)/F 4/H/N/Rect[334.35 642.855 339.761 630.444]/Subtype/Link/Type/Annot>> endobj 371 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:38. Feinberg, K. etal. A glial signal consisting of gliomedin and NrCAM cl\ usters axonal Na+ channels during the formation of nodes of Ranvier. 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Brivio, V., Faivre-Sarrailh, C., Peles, E., Sherman, D. L. & Brophy, P. J. \ Assembly of CNS nodes of Ranvier in myelinated nerves is promoted by the axon cytoskeleton. Curr. Biol. 27, 1068 1073 \(2017\ \). \nThis paper supports the role of the :203)/F 4/H/N/Rect[173.675 554.855 178.874 542.444]/Subtype/Link/Type/Annot>> endobj 375 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Fig. 2 | Two overlapping axoglial adhesion systems assemble the nodes of Ranv\ ier. \na | The initial clustering of Na+ channels occurs at heminodes that flank each of the \nforming myelin segments an\ d paranodal loops \(PNL\). This clustering :204)/F 4/H/N/Rect[232.694 532.855 240.863 520.444]/Subtype/Link/Type/Annot>> endobj 376 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:37. Eshed, Y. etal. Gliomedin mediates schwann cell-axon interaction and th\ e molecular assembly of the nodes of ranvier. 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Gliomedin mediates schwann cell-axon interaction and \ the molecular assembly of the nodes of ranvier. Neuron 47, 215 229 \(2005\). \nThis paper shows that gliomedin is the Schwan\ n cell-derived factor that interacts with :212)/F 4/H/N/Rect[281.012 411.855 286.28 399.444]/Subtype/Link/Type/Annot>> endobj 384 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Fig. 3 | Molecular interactions at the nodes of Ranvier. Peripheral nerv\ ous system \(PNS\) nodes of the Ranvier \(NOR\) are surrounded by several interacting and glia- derived proteins. Gliomedin and Nr\ CAM bind to neurofascin 186 \(NF186\) and fu:213)/F 4/H/N/Rect[305.887 411.855 310.435 399.444]/Subtype/Link/Type/Annot>> endobj 385 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:38. Feinberg, K. etal. A glial signal consisting of gliomedin and NrCAM c\ lusters axonal Na+ channels during the formation of nodes of Ranvier. Neuron 65, 490 502 \(2010\). \nThis paper shows that\ gliomedin and NrCAM function as the prima:214)/F 4/H/N/Rect[305.784 378.974 310.978 366.444]/Subtype/Link/Type/Annot>> endobj 386 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:48. Amor, V. etal. The paranodal cytoskeleton clusters Na+ channels at nod\ es of Ranvier. eLife 6, e21392 \(2017\). \nThis paper shows that, in the absence of NF186, the paranodal 2 spectrin-depende\ nt cytoskeleton clusters nodal Na+ c:215)/F 4/H/N/Rect[334.401 367.974 339.761 355.444]/Subtype/Link/Type/Annot>> endobj 387 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:37. Eshed, Y. etal. Gliomedin mediates schwann cell-axon interaction and\ the molecular assembly of the nodes of ranvier. Neuron 47, 215 229 \(2005\). \nThis paper shows that gliomedin is the Schwa\ nn cell-derived factor that interacts with:216)/F 4/H/N/Rect[307.155 345.855 312.406 333.444]/Subtype/Link/Type/Annot>> endobj 388 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:63. Labasque, M., Devaux, J. J., Leveque, C. & Faivre-Sarrailh, C. Fibronectin \ type III-like domains of neurofascin-186 protein mediate gliomedin binding and its clustering at the developing nodes of Ranvier\ . J. Biol. Chem. 286, 42426 42434 \(2:217)/F 4/H/N/Rect[313.68 345.855 318.932 333.444]/Subtype/Link/Type/Annot>> endobj 389 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:61. Eshed, Y., Feinberg, K., Carey, D. J. & Peles, E. Secreted gliomedin is a \ perinodal matrix component of peripheral nerves. J. Cell Biol. 177, 551 562 \(2007\).\r:218)/F 4/H/N/Rect[539.272 730.855 544.367 718.444]/Subtype/Link/Type/Annot>> endobj 390 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:62. Maertens, B. etal. Cleavage and oligomerization \nof gliomedin, a transmem\ brane collagen required \nfor node of ranvier formation. J. Biol. Chem. 282, 10647 10659 \(2007\).\r:219)/F 4/H/N/Rect[545.563 730.855 550.658 718.444]/Subtype/Link/Type/Annot>> endobj 391 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:61. Eshed, Y., Feinberg, K., Carey, D. J. & Peles, E. Secreted gliomedin is a\ perinodal matrix component of peripheral nerves. J. Cell Biol. 177, 551 562 \(2007\).\r:220)/F 4/H/N/Rect[471.195 697.855 476.362 685.444]/Subtype/Link/Type/Annot>> endobj 392 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:64. Han, H. & Kursula, P. The olfactomedin domain from gliomedin is a beta-prop\ eller with unique structural properties. J. Biol. 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Neuron https://doi.org/10.1016/j.neuron.2020.03.0\ 01 \(2020\). \nThis paper describes ho:233)/F 4/H/N/Rect[547.572 367.855 552.756 355.444]/Subtype/Link/Type/Annot>> endobj 405 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:61. Eshed, Y., Feinberg, K., Carey, D. J. & Peles, E. Secreted gliomedin is \ a perinodal matrix component of peripheral nerves. J. Cell Biol. 177, 551 562 \(2007\).\r:234)/F 4/H/N/Rect[372.6 334.855 377.695 322.444]/Subtype/Link/Type/Annot>> endobj 406 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:66. Colombelli, C. etal. Perlecan is recruited by dystroglycan to nodes of R\ anvier and binds the clustering molecule gliomedin. J. Cell Biol. 208, \n313 329 \(2015\).\r:235)/F 4/H/N/Rect[378.891 334.855 383.987 322.444]/Subtype/Link/Type/Annot>> endobj 407 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:61. Eshed, Y., Feinberg, K., Carey, D. J. & Peles, E. Secreted gliomedin is\ a perinodal matrix component of peripheral nerves. J. Cell Biol. 177, 551 562 \(2007\).\r:236)/F 4/H/N/Rect[442.602 290.855 447.656 278.444]/Subtype/Link/Type/Annot>> endobj 408 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:62. Maertens, B. etal. Cleavage and oligomerization \nof gliomedin, a transme\ mbrane collagen required \nfor node of ranvier formation. J. Biol. Chem. 282, 10647 10659 \(2007\).\r:237)/F 4/H/N/Rect[448.832 290.855 453.886 278.444]/Subtype/Link/Type/Annot>> endobj 409 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:65. Eshed-Eisenbach, Y. etal. Precise Spatiotemporal control of nodal Na+ c\ hannel clustering by bone morphogenetic protein-1/tolloid-like proteinases. 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Anti-GM1 antibodies cause complement-mediated disruption\ of sodium channel clusters in peripheral motor nerve fibers. J. Neurosci. 27, 3956 3967 \(2007\).\r:187)/F 4/H/N/Rect[125.96 93.0211 133.145 83.7551]/Subtype/Link/Type/Annot>> endobj 438 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:172. Vural, A., Doppler, K. & Meinl, E. Autoantibodies against the node of ranv\ ier in seropositive chronic inflammatory demyelinating polyneuropathy: diagnostic, pathogenic, and therapeutic \nrelevance. Fro\ nt. Immunol. 9, 1029 \(2018\).\r:188)/F 4/H/N/Rect[245.523 93.0211 252.709 83.7551]/Subtype/Link/Type/Annot>> endobj 439 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:173. Vallat, J. M. etal. Ultrastructural lesions of nodo-\nparanodopathies in p\ eripheral neuropathies. \nJ. Neuropathol. Exp. Neurol. 79, 247 255 \n\(2020\).\r:189)/F 4/H/N/Rect[139.497 73.0211 146.682 63.7551]/Subtype/Link/Type/Annot>> endobj 440 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:175. Doppler, K. etal. Anti-CNTN1 IgG3 induces acute conduction block and moto\ r deficits in a passive transfer rat model. J. Neuroinflammation 16, 73 \(2019\).\r:190)/F 4/H/N/Rect[148.828 73.0211 156.013 63.7551]/Subtype/Link/Type/Annot>> endobj 441 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:176. Kouton, L. etal. Electrophysiological features \nof chronic inflammatory d\ emyelinating polyradiculoneuropathy associated with IgG4 antibodies targeting neurofascin 155 or contactin 1 glycoproteins. Cl\ in. 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Differential expression \nof proteoglycans a\ t central and peripheral nodes of Ranvier. Glia 52, 301 308 \(2005\).\r:244)/F 4/H/N/Rect[192.039 455.855 197.337 443.444]/Subtype/Link/Type/Annot>> endobj 455 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:69. Goutebroze, L., Carnaud, M., Denisenko, N., Boutterin, M. C. & Girault, J\ . A. Syndecan-3 and syndecan-4 are enriched in Schwann cell perinodal processes. BMC Neurosci. 4, 29 \(2003\).\r:245)/F 4/H/N/Rect[198.634 455.855 203.931 443.444]/Subtype/Link/Type/Annot>> endobj 456 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:66. Colombelli, C. etal. Perlecan is recruited by dystroglycan to nodes of\ Ranvier and binds the clustering molecule gliomedin. J. Cell Biol. 208, \n313 329 \(2015\).\r:246)/F 4/H/N/Rect[282.429 455.855 287.726 443.444]/Subtype/Link/Type/Annot>> endobj 457 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Table 1 | Adhesion, ECM and cytoskeletal components of the nodes of Ranvier\ \r:247)/F 4/H/N/Rect[315.695 455.855 320.266 443.444]/Subtype/Link/Type/Annot>> endobj 458 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:66. Colombelli, C. etal. Perlecan is recruited by dystroglycan to nodes o\ f Ranvier and binds the clustering molecule gliomedin. J. Cell Biol. 208, \n313 329 \(2015\).\r:248)/F 4/H/N/Rect[207.342 433.855 212.479 421.444]/Subtype/Link/Type/Annot>> endobj 459 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:70. Saito, F. etal. Unique role of dystroglycan in peripheral nerve myelinati\ on, nodal structure, and sodium channel stabilization. Neuron 38, 747 758 \(2003\).\r:249)/F 4/H/N/Rect[181.087 389.855 186.297 377.444]/Subtype/Link/Type/Annot>> endobj 460 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:38. Feinberg, K. etal. A glial signal consisting of gliomedin and NrC\ AM clusters axonal Na+ channels during the formation of nodes of Ranvier. Neuron 65, 490 502 \(2010\). \nThis paper shows \ that gliomedin and NrCAM function as the p:250)/F 4/H/N/Rect[184.355 378.855 189.641 366.444]/Subtype/Link/Type/Annot>> endobj 461 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:66. Colombelli, C. etal. Perlecan is recruited by dystroglycan to nodes \ of Ranvier and binds the clustering molecule gliomedin. J. 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Neuron 78, \n469 482 \(2013\). \nThis paper reveals perinodal NF186-interacting ECM molecules that function as\ a secondary mechanism after paranodal jun:254)/F 4/H/N/Rect[211.164 169.855 216.328 157.444]/Subtype/Link/Type/Annot>> endobj 465 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:71. Bekku, Y., Rauch, U., Ninomiya, Y. & Oohashi, T. Brevican distinctively \ assembles extracellular components at the large diameter nodes of Ranvier \nin the CNS. J. Neurochem. 108, 1266 1276 \(2009\)\ .\r:255)/F 4/H/N/Rect[217.559 169.855 222.723 157.444]/Subtype/Link/Type/Annot>> endobj 466 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:73. Oohashi, T. etal. Bral1, a brain-specific link protein, colocalizing w\ ith the versican V2 isoform at the nodes of Ranvier in developing and adult mouse central nervous systems. Mol. Cell Neurosci.\ 19, 43 57 \(2002\).\r:256)/F 4/H/N/Rect[225.52 169.855 230.685 157.444]/Subtype/Link/Type/Annot>> endobj 467 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Fig. 1 | Organization of the nodal environ. a | Myelin formed \ by Schwann cells or \noligodendrocytes \(not shown\) covers the axon in segments \(internodes\) separated by \nthe nodes of Ranvier\ . The nodes of Ranvier, which are flanked b:257)/F 4/H/N/Rect[253.472 169.855 257.937 157.444]/Subtype/Link/Type/Annot>> endobj 468 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Fig. 3 | Molecular interactions at the nodes of Ranvier. Peripheral ner\ vous system \(PNS\) nodes of the Ranvier \(NOR\) are surrounded by several interacting and glia- derived proteins. Gliomedin and N\ rCAM bind to neurofascin 186 \(NF186\) and f:258)/F 4/H/N/Rect[262.037 169.855 266.502 157.444]/Subtype/Link/Type/Annot>> endobj 469 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:74. Bekku, Y. etal. Bral1: its role in diffusion barrier formation and conduct\ ion velocity in the CNS. \nJ. Neurosci. 30, 3113 3123 \(2010\).\r:259)/F 4/H/N/Rect[311.98 147.855 317.343 135.444]/Subtype/Link/Type/Annot>> endobj 470 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:39. Susuki, K. etal. Three mechanisms assemble central nervous system no\ des of Ranvier. Neuron 78, \n469 482 \(2013\). \nThis paper reveals perinodal NF186-interacting ECM molecules that function a\ s a secondary mechanism after paranodal ju:260)/F 4/H/N/Rect[334.63 114.855 339.761 102.444]/Subtype/Link/Type/Annot>> endobj 471 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:75. Weber, P. etal. Mice deficient for tenascin-R display alterations of the e\ xtracellular matrix and decreased axonal conduction velocities in the CNS. J. Neurosci. 19, 4245 4262 \(1999\).\r:261)/F 4/H/N/Rect[282.749 81.8547 287.844 69.4439]/Subtype/Link/Type/Annot>> endobj 472 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:71. Bekku, Y., Rauch, U., Ninomiya, Y. & Oohashi, T. Brevican distinctively\ assembles extracellular components at the large diameter nodes of Ranvier \nin the CNS. J. Neurochem. 108, 1266 1276 \(2009\)\ .\r:262)/F 4/H/N/Rect[309.798 70.8547 314.917 58.4439]/Subtype/Link/Type/Annot>> endobj 473 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:76. Dours-Zimmermann, M. T. etal. Versican V2 assembles the extracellular matr\ ix surrounding \nthe nodes of ranvier in the CNS. J. Neurosci. 29, 7731 7742 \(2009\).\r:263)/F 4/H/N/Rect[316.125 70.8547 321.244 58.4439]/Subtype/Link/Type/Annot>> endobj 474 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:77. Bekku, Y. & Oohashi, T. Neurocan contributes to \nthe molecular heterogenei\ ty of the perinodal ECM. Arch. Histol. Cytol. 73, 95 102 \(2010\).\r:264)/F 4/H/N/Rect[334.733 59.8547 339.912 47.4439]/Subtype/Link/Type/Annot>> endobj 475 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:39. Susuki, K. etal. Three mechanisms assemble central nervous system n\ odes of Ranvier. Neuron 78, \n469 482 \(2013\). \nThis paper reveals perinodal NF186-interacting ECM molecules that function \ as a secondary mechanism after paranodal j:265)/F 4/H/N/Rect[426.465 730.855 431.489 718.444]/Subtype/Link/Type/Annot>> endobj 476 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:78. Fawcett, J. W., Oohashi, T. & Pizzorusso, T. The roles of perineuronal nets\ and the perinodal extracellular matrix in neuronal function. Nat. Rev. Neurosci. 20, 451 465 \(2019\).\r:266)/F 4/H/N/Rect[382.876 631.855 387.971 619.444]/Subtype/Link/Type/Annot>> endobj 477 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:48. Amor, V. etal. The paranodal cytoskeleton clusters Na+ channels at \ nodes of Ranvier. eLife 6, e21392 \(2017\). \nThis paper shows that, in the absence of NF186, the paranodal 2 spectrin-depe\ ndent cytoskeleton clusters nodal Na+:267)/F 4/H/N/Rect[368.24 576.855 373.335 564.444]/Subtype/Link/Type/Annot>> endobj 478 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:39. Susuki, K. etal. Three mechanisms assemble central nervous system \ nodes of Ranvier. Neuron 78, \n469 482 \(2013\). \nThis paper reveals perinodal NF186-interacting ECM molecules that function\ as a secondary mechanism after paranodal :268)/F 4/H/N/Rect[420.787 521.855 426.025 509.444]/Subtype/Link/Type/Annot>> endobj 479 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:38. Feinberg, K. etal. A glial signal consisting of gliomedin and Nr\ CAM clusters axonal Na+ channels during the formation of nodes of Ranvier. Neuron 65, 490 502 \(2010\). \nThis paper shows\ that gliomedin and NrCAM function as the :269)/F 4/H/N/Rect[382.951 499.855 388.046 487.444]/Subtype/Link/Type/Annot>> endobj 480 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:39. Susuki, K. etal. Three mechanisms assemble central nervous system\ nodes of Ranvier. Neuron 78, \n469 482 \(2013\). \nThis paper reveals perinodal NF186-interacting ECM molecules that functio\ n as a secondary mechanism after paranodal:270)/F 4/H/N/Rect[434.83 433.855 439.885 421.444]/Subtype/Link/Type/Annot>> endobj 481 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:37. Eshed, Y. etal. Gliomedin mediates schwann cell-axon interaction\ and the molecular assembly of the nodes of ranvier. Neuron 47, 215 229 \(2005\). \nThis paper shows that gliomedin is the S\ chwann cell-derived factor that interacts :271)/F 4/H/N/Rect[545.44 367.855 550.658 355.444]/Subtype/Link/Type/Annot>> endobj 482 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:39. Susuki, K. etal. Three mechanisms assemble central nervous syste\ m nodes of Ranvier. 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Bekku, Y. etal. Bral1: its role in diffusion barrier formation and condu\ ction velocity in the CNS. \nJ. Neurosci. 30, 3113 3123 \(2010\).\r:277)/F 4/H/N/Rect[292.424 708.855 297.519 696.444]/Subtype/Link/Type/Annot>> endobj 503 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:10. Pan, Z. etal. A common ankyrin-G-based mechanism retains KCNQ and Nav chan\ nels at electrically active domains of the axon. J. Neurosci. 26, 2599 2613 \(2006\).\r:278)/F 4/H/N/Rect[302.513 642.855 307.975 630.444]/Subtype/Link/Type/Annot>> endobj 504 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:79. Tuvia, S., Garver, T. D. & Bennett, V. The phosphorylation state of the FIG\ QY tyrosine of neurofascin determines ankyrin-binding activity and patterns of cell segregation. Proc. Natl Acad. Sci. USA 94\ , 12957 12962 \(1997\).\r:279)/F 4/H/N/Rect[309.355 642.855 314.818 630.444]/Subtype/Link/Type/Annot>> endobj 505 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:82. Xu, M. & Cooper, E. C. An ankyrin-G N-terminal gate and protein kinase CK2 \ dually regulate binding of voltage-gated sodium and KCNQ2/3 potassium channels. J. Biol. Chem. 290, 16619 16632 \(2015\).\r:\ 280)/F 4/H/N/Rect[317.764 642.855 323.226 630.444]/Subtype/Link/Type/Annot>> endobj 506 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:80. Garrido, J. J. etal. A targeting motif involved in sodium channel clusteri\ ng at the axonal initial segment. Science 300, 2091 2094 \(2003\).\r:281)/F 4/H/N/Rect[194.743 598.855 200.252 586.444]/Subtype/Link/Type/Annot>> endobj 507 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:81. Lemaillet, G., Walker, B. & Lambert, S. 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TREK-1 and TRAAK are principal \nK+ channels at the node\ s of Ranvier for rapid action potential conduction on mammalian myelinated afferent nerves. Neuron 104, 960 971.e7 \(2019\).\ \nThis paper reveals the long-sought for :294)/F 4/H/N/Rect[543.782 598.974 546.524 586.444]/Subtype/Link/Type/Annot>> endobj 520 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:9. Brohawn, S. G. etal. The mechanosensitive ion channel TRAAK is localized t\ o the mammalian node \nof Ranvier. eLife 8, e50403 \(2019\).\r:295)/F 4/H/N/Rect[547.916 598.974 550.658 586.444]/Subtype/Link/Type/Annot>> endobj 521 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:90. Ho, T. S. etal. A hierarchy of ankyrin-spectrin complexes clusters sodiu\ m channels at nodes of Ranvier. Nat. Neurosci. 17, 1664 1672 \(2014\). \nThis paper demonstrates that both AnkG and \nAnkR ca\ n function at the nodes of Ranvier to clus:296)/F 4/H/N/Rect[401.82 499.974 406.944 487.444]/Subtype/Link/Type/Annot>> endobj 522 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:90. Ho, T. S. etal. A hierarchy of ankyrin-spectrin complexes clusters sodi\ um channels at nodes of Ranvier. Nat. Neurosci. 17, 1664 1672 \(2014\). \nThis paper demonstrates that both AnkG and \nAnkR c\ an function at the nodes of Ranvier to clu:297)/F 4/H/N/Rect[411.432 444.974 416.654 432.444]/Subtype/Link/Type/Annot>> endobj 523 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:91. Gumy, L. F. etal. MAP2 defines a pre-axonal filtering zone to regulate KIF\ 1- versus KIF5-dependent cargo transport in sensory neurons. Neuron 94, 347 362 \(2017\).\r:298)/F 4/H/N/Rect[535.214 411.855 540.299 399.444]/Subtype/Link/Type/Annot>> endobj 524 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:90. Ho, T. S. etal. A hierarchy of ankyrin-spectrin complexes clusters sod\ ium channels at nodes of Ranvier. Nat. Neurosci. 17, 1664 1672 \(2014\). \nThis paper demonstrates that both AnkG and \nAnkR \ can function at the nodes of Ranvier to cl:299)/F 4/H/N/Rect[383.953 224.855 389.062 212.444]/Subtype/Link/Type/Annot>> endobj 525 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Fig. 3 | Molecular interactions at the nodes of Ranvier. Peripheral ne\ rvous system \(PNS\) nodes of the Ranvier \(NOR\) are surrounded by several interacting and glia- derived proteins. Gliomedin and \ NrCAM bind to neurofascin 186 \(NF186\) and :300)/F 4/H/N/Rect[368.637 180.855 372.989 168.444]/Subtype/Link/Type/Annot>> endobj 526 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:92. Jenkins, P. M. etal. Giant ankyrin-G: a critical innovation in vertebrate \ evolution of fast and integrated neuronal signaling. Proc. Natl Acad. \nSci. USA 112, 957 964 \(2015\).\r:301)/F 4/H/N/Rect[437.321 158.855 442.553 146.444]/Subtype/Link/Type/Annot>> endobj 527 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:93. Liu, C. H. etal. Nodal  spectrins are required to maintain Na+ channel \ clustering and axon integrity. eLife 9, e52378 \(2020\).\r:302)/F 4/H/N/Rect[443.817 158.855 449.049 146.444]/Subtype/Link/Type/Annot>> endobj 528 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:93. Liu, C. H. etal. Nodal  spectrins are required to maintain Na+ channel\ clustering and axon integrity. eLife 9, e52378 \(2020\).\r:303)/F 4/H/N/Rect[547.517 136.855 552.756 124.444]/Subtype/Link/Type/Annot>> endobj 529 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Fig. 3 | Molecular interactions at the nodes of Ranvier. Peripheral n\ ervous system \(PNS\) nodes of the Ranvier \(NOR\) are surrounded by several interacting and glia- derived proteins. 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Neurosci. \n37, 2524 2538 \(2017:307)/F 4/H/N/Rect[181.592 565.855 186.687 553.444]/Subtype/Link/Type/Annot>> endobj 574 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:86. Zhou, D. etal. AnkyrinG is required for clustering of voltage-gated Na ch\ annels at axon initial segments and for normal action potential firing. J. Cell Biol. 143, 1295 1304 \(1998\).\r:308)/F 4/H/N/Rect[307.581 521.855 312.781 509.444]/Subtype/Link/Type/Annot>> endobj 575 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:95. Schafer, D. P. etal. Disruption of the axon initial segment cytoskeleton i\ s a new mechanism for neuronal injury. J. Neurosci. 29, 13242 13254 \(2009\).\r:309)/F 4/H/N/Rect[300.652 499.855 305.747 487.444]/Subtype/Link/Type/Annot>> endobj 576 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:96. Clark, K. C. etal. Compromised axon initial segment integrity in EAE is pr\ eceded by microglial reactivity and contact. 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D Este, E., Kamin, D., Balzarotti, F. & Hell, S. W. Ultrastructural anatom\ y of nodes of Ranvier in the peripheral nervous system as revealed by STED microscopy. Proc. Natl Acad. Sci. USA 114, 191 19\ 9 \(2017\).\r:316)/F 4/H/N/Rect[323.515 378.855 331.057 366.444]/Subtype/Link/Type/Annot>> endobj 583 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:104. Huang, C. Y., Zhang, C., Zollinger, D. R., Leterrier, C. \n& Rasband, M. N\ . An II spectrin-based cytoskeleton protects large-diameter myelinated axons from degeneration. J. Neurosci. 37, 11323 113\ 34 \(2017\).\r:317)/F 4/H/N/Rect[332.219 378.855 339.761 366.444]/Subtype/Link/Type/Annot>> endobj 584 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:105. Yang, Y., Lacas-Gervais, S., Morest, D. K., Solimena, M. & Rasband, M. N. \ IV spectrins are essential for membrane stability and the molecular organization \nof nodes of Ranvier. J. Neurosci. 24, 72\ 30 7240 \(2004\).\r:318)/F 4/H/N/Rect[165.042 345.855 173.055 333.444]/Subtype/Link/Type/Annot>> endobj 585 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Box 1 | Involvement of nodal environ components in human diseases\rThe import\ ance of the nodes of Ranvier to the normal function of the nervous system \nis reinforced by the involvement of different nodal \ as well as paranodal components \nin neuro:319)/F 4/H/N/Rect[283.702 279.855 288.139 267.444]/Subtype/Link/Type/Annot>> endobj 586 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:106. Wang, C. C. etal. IV spectrinopathies cause profound intellectual disab\ ility, congenital hypotonia, and \nmotor axonal neuropathy. Am. J. Hum. Genet. 102, 1158 1168 \(2018\).\r:320)/F 4/H/N/Rect[186.884 257.855 195.027 245.444]/Subtype/Link/Type/Annot>> endobj 587 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:104. Huang, C. Y., Zhang, C., Zollinger, D. R., Leterrier, C. \n& Rasband, M. \ N. An II spectrin-based cytoskeleton protects large-diameter myelinated axons from degeneration. J. Neurosci. 37, 11323 11\ 334 \(2017\).\r:321)/F 4/H/N/Rect[295.811 213.855 303.429 201.444]/Subtype/Link/Type/Annot>> endobj 588 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:104. Huang, C. Y., Zhang, C., Zollinger, D. R., Leterrier, C. \n& Rasband, M.\ N. An II spectrin-based cytoskeleton protects large-diameter myelinated axons from degeneration. J. Neurosci. 37, 11323 1\ 1334 \(2017\).\r:322)/F 4/H/N/Rect[322.813 169.855 330.656 157.444]/Subtype/Link/Type/Annot>> endobj 589 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:107. Zhang, C., Susuki, K., Zollinger, D. R., Dupree, J. L. \n& Rasband, M. N. M\ embrane domain organization \nof myelinated axons requires II spectrin. J. Cell Biol. 203, 437 443 \(2013\). \nThis paper d\ emonstrates the molecular basis of the para:323)/F 4/H/N/Rect[331.918 169.855 339.761 157.444]/Subtype/Link/Type/Annot>> endobj 590 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:93. Liu, C. H. etal. Nodal  spectrins are required to maintain Na+ channe\ l clustering and axon integrity. eLife 9, e52378 \(2020\).\r:324)/F 4/H/N/Rect[312.661 125.855 318.005 113.444]/Subtype/Link/Type/Annot>> endobj 591 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:93. Liu, C. H. etal. Nodal  spectrins are required to maintain Na+ chann\ el clustering and axon integrity. eLife 9, e52378 \(2020\).\r:325)/F 4/H/N/Rect[538.323 598.855 543.607 586.444]/Subtype/Link/Type/Annot>> endobj 592 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:104. Huang, C. Y., Zhang, C., Zollinger, D. R., Leterrier, C. \n& Rasband, M\ . N. An II spectrin-based cytoskeleton protects large-diameter myelinated axons from degeneration. J. Neurosci. 37, 11323 \ 11334 \(2017\).\r:326)/F 4/H/N/Rect[544.897 598.855 552.756 586.444]/Subtype/Link/Type/Annot>> endobj 593 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:101. Vassilopoulos, S., Gibaud, S., Jimenez, A., Caillol, G. \n& Leterrier, C. \ Ultrastructure of the axonal periodic scaffold reveals a braid-like organization of actin rings. Nat. Commun. 10, 5803 \(201\ 9\).\r:327)/F 4/H/N/Rect[433.225 499.855 441.089 487.444]/Subtype/Link/Type/Annot>> endobj 594 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:102. Dubey, S. etal. The axonal actin-spectrin lattice \nacts as a tension buf\ fering shock absorber. eLife https://doi.org/10.7554/eLife.51772 \(2020\).\r:328)/F 4/H/N/Rect[399.074 477.855 406.694 465.444]/Subtype/Link/Type/Annot>> endobj 595 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:93. Liu, C. H. etal. Nodal  spectrins are required to maintain Na+ chan\ nel clustering and axon integrity. eLife 9, e52378 \(2020\).\r:329)/F 4/H/N/Rect[401.999 455.855 407.224 443.444]/Subtype/Link/Type/Annot>> endobj 596 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:104. Huang, C. Y., Zhang, C., Zollinger, D. R., Leterrier, C. \n& Rasband, \ M. N. An II spectrin-based cytoskeleton protects large-diameter myelinated axons from degeneration. J. Neurosci. 37, 11323 \ 11334 \(2017\).\r:330)/F 4/H/N/Rect[408.484 455.855 416.321 443.444]/Subtype/Link/Type/Annot>> endobj 597 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:15. Vabnick, I., Novakovic, S. D., Levinson, S. R., Schachner, M. & Shrager, P\ . The clustering of \naxonal sodium channels during development of the peripheral nervous system. J. Neurosci. 16, \n4914 492\ 2 \(1996\).\r:331)/F 4/H/N/Rect[370.669 279.855 375.686 267.444]/Subtype/Link/Type/Annot>> endobj 598 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:18. Rasband, M. N. etal. Dependence of nodal sodium channel clustering on pa\ ranodal axoglial contact \nin the developing CNS. J. Neurosci. 19, 7516 7528 \(1999\).\r:332)/F 4/H/N/Rect[376.844 279.855 381.862 267.444]/Subtype/Link/Type/Annot>> endobj 599 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:21. Dugandzija-Novakovic, S., Koszowski, A. G., \nLevinson, S. R. & Shrager, P.\ Clustering of \nNa+ channels and node of Ranvier formation in remyelinating axons. J. Neurosci. 15, 492 503 \(1995\).\r:333)/F 4/H/N/Rect[383.019 279.855 388.037 267.444]/Subtype/Link/Type/Annot>> endobj 600 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:108. Pedraza, L., Huang, J. K. & Colman, D. R. Organizing principles of the axo\ glial apparatus. Neuron 30, \n335 344 \(2001\).\r:334)/F 4/H/N/Rect[389.194 279.855 396.721 267.444]/Subtype/Link/Type/Annot>> endobj 601 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:38. Feinberg, K. etal. A glial signal consisting of gliomedin and N\ rCAM clusters axonal Na+ channels during the formation of nodes of Ranvier. Neuron 65, 490 502 \(2010\). \nThis paper show\ s that gliomedin and NrCAM function as the:335)/F 4/H/N/Rect[500.112 257.855 505.348 245.444]/Subtype/Link/Type/Annot>> endobj 602 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:43. Zonta, B. etal. Glial and neuronal isoforms of neurofascin have distinct\ roles in the assembly \nof nodes of Ranvier in the central nervous system. \nJ. Cell Biol. 181, 1169 1177 \(2008\). \nThis p\ aper shows that neuronal or glial neurofasc:336)/F 4/H/N/Rect[506.614 257.855 511.85 245.444]/Subtype/Link/Type/Annot>> endobj 603 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:48. Amor, V. etal. The paranodal cytoskeleton clusters Na+ channels a\ t nodes of Ranvier. eLife 6, e21392 \(2017\). \nThis paper shows that, in the absence of NF186, the paranodal 2 spectrin-de\ pendent cytoskeleton clusters nodal Na+:337)/F 4/H/N/Rect[513.117 257.855 518.352 245.444]/Subtype/Link/Type/Annot>> endobj 604 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:41. Tait, S. etal. An oligodendrocyte cell adhesion molecule at the site of a\ ssembly of the paranodal axo-glial junction. J. Cell Biol. 150, 657 666 \(2000\).\r:338)/F 4/H/N/Rect[501.994 202.855 507.12 190.444]/Subtype/Link/Type/Annot>> endobj 605 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:45. Boyle, M. E. etal. Contactin orchestrates assembly \nof the septate-like ju\ nctions at the paranode in myelinated peripheral nerve. Neuron 30, 385 397 \(2001\).\r:339)/F 4/H/N/Rect[508.332 202.855 513.459 190.444]/Subtype/Link/Type/Annot>> endobj 606 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:109. Peles, E. etal. Identification of a novel contactin-associated transmembr\ ane receptor with multiple domains implicated in protein-protein interactions. EMBO J. 16, 978 988 \(1997\).\r:340)/F 4/H/N/Rect[514.671 202.855 522.36 190.444]/Subtype/Link/Type/Annot>> endobj 607 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Fig. 1 | Organization of the nodal environ. a | Myelin forme\ d by Schwann cells or \noligodendrocytes \(not shown\) covers the axon in segments \(internodes\) separated by \nthe nodes of Ranvi\ er. The nodes of Ranvier, which are flanked:341)/F 4/H/N/Rect[540.86 202.855 548.687 190.444]/Subtype/Link/Type/Annot>> endobj 608 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:110. Charles, P. etal. Neurofascin is a glial receptor for \nthe paranodin/Casp\ r-contactin axonal complex at the axoglial junction. Curr. Biol. 12, 217 220 \(2002\).\r:342)/F 4/H/N/Rect[400.355 180.855 407.998 168.444]/Subtype/Link/Type/Annot>> endobj 609 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:111. Gollan, L., Salomon, D., Salzer, J. L. & Peles, E. Caspr regulates the pro\ cessing of contactin and inhibits its binding to neurofascin. J. Cell Biol. 163, 1213 1218 \(2003\).\r:343)/F 4/H/N/Rect[409.194 180.855 416.837 168.444]/Subtype/Link/Type/Annot>> endobj 610 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:42. Pillai, A. M. etal. Spatiotemporal ablation of myelinating glia-specific\ neurofascin \(Nfasc NF155\) \nin mice reveals gradual loss of paranodal axoglial junctions and concomitant disorganization of ax\ onal domains. J. Neurosci. Res. 87, 17:344)/F 4/H/N/Rect[374.671 136.855 379.915 124.444]/Subtype/Link/Type/Annot>> endobj 611 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:44. Bhat, M. A. etal. Axon-glia interactions and the domain organization of m\ yelinated axons requires neurexin IV/Caspr/Paranodin. Neuron 30, 369 383 \(2001\).\r:345)/F 4/H/N/Rect[381.186 136.855 386.43 124.444]/Subtype/Link/Type/Annot>> endobj 612 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:45. Boyle, M. E. etal. Contactin orchestrates assembly \nof the septate-like j\ unctions at the paranode in myelinated peripheral nerve. Neuron 30, 385 397 \(2001\).\r:346)/F 4/H/N/Rect[387.701 136.855 392.945 124.444]/Subtype/Link/Type/Annot>> endobj 613 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Box 1 | Involvement of nodal environ components in human diseases\rThe impor\ tance of the nodes of Ranvier to the normal function of the nervous system \nis reinforced by the involvement of different nodal\ as well as paranodal components \nin neur:347)/F 4/H/N/Rect[474.101 114.855 478.511 102.444]/Subtype/Link/Type/Annot>> endobj 614 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/XObject<>>> endobj 615 0 obj <>stream x}r#Iv~`#4 LeV3=kOKr8hHb=T%z 'oҞ`D]2;z,߽77P;n0]U ).ެʪߌ+9<MQM]mǪl7?.>SUxZեZ[5\;j6ŲZlb٬ZKNvE%yѥ z}#z?XVjKlmla_5 }ծarɋ7Ų#/[G& wfn[z,_BI]ꉭ`@'W;Vɶ։LqT1Cz("Bm"y_ILҿ+/tب7`aA͆Vey0=HA5'e?=!u:W/Y {Ϋ仃`1poܰOV?[D5ykt8jmc<,n 'ϹחyЇJQo(d*8PgCJ=Wͻ}":]i9ꅠ\ri]r0]~ѽ;X}Eoeo_FV]:Xj5 MgL\5XuPǑXBn15X] vzʪES>T$ӊtyB;9ZN;o nICۅ1!D!o t?3K^x#;??hYWꇄcw:T]P#(J{ ڮb.'ٷȣ%on[A)IIqw-AB땀sqI JQ'CUxJ8:HaG7K5ѱ(*%8*x-kcQ{yaP?@ $w{܎h qk 3Y Y׫_{BsJ0,!fdʲ 7<-l)avڛ׍یڨ2~}DbxF((l&D8U߯ʡoD;@A뷛ǧ_/o 8?o}e~gܶTkUPD /ʴC@cld Zts7ܵ%V`UPtȜCq%zuV?|~Ajggwp;]UR=1@Mڱs3&|7 b QhoE5i|:z Ԏ%;`at 1 `pߡ6_ lP|jlVuFjJ+ߕľᖜO v>TLڥthv©Pb+4l"w.88pV5yU3&wWYn@j tęl:{4~uxRf: ~x?MD9e]!,irķDӋoKgH-¯R\'El3 %H[68C3:0IȪx H|SVxɒLkjV1ACva `"ߒ3u@.bfir'J;8N.P;6Jft[+Ј_#a3tb<$7Qȏ saDu'liL\Gvt" Da"t#u&(oWpOThdO !:>\ >=? |_Z[!{š L DܳX=8حh˛}yG?D2|ZH@|v{JX+dBk`Drݢׇ}͟ z8:ݛ*PÃN]H>}c1r&nQq7ʷ'bi3Q{qP3e,ե *x>jC.f-4TB+6{㜭Q:lZfJ[mzo\'=a:JONwۋxKxaf൥PrLm0fT!Iґx6,Gw,=(~cQ3zV?UǜKG0[XP`RBCٷQV+~o7io8=fBo1,mՏ(Dʤț>"ÖAjU(~s-_AͲ[<]>Rcp:'=@9 c׏2Iݠ>H!kBj@Vww*2m6eՃ]V$>}"HuA2љI< @{m U:1-I{5?S[HcAsKĺ)<[J0^>F?D}A@DZ 1ˢdw[/+%S>0`J "(6Ő%1kР^CCw CnOᶐQE6h83sc4k<_?h2EZLQM?YP4΀:9R ,Jtm4޻gyKv2۪C Ɠ_z}!h8 ̩vVFؕXC:PK#W] RG:4KlQEj SP@PҌnt[ e@-M|ɄaD=q6bU,zz $d=6KTAC%y7XeW{?B{<ޛ~sn!M~H;( 5H(.ׅHre- xϸ"HZ5duDwi&Yd q^Hly}5O4E~Mq904h@fCO$pqo}3M88ʎ0>= 3) f-{ҬrCj=O8 2 CH9ccw; aU|"v31x%Rc:z!H8I5<h #*za6їazPkܮ9 -8tG?jH} @ٶXg]iTBgut᪬EVDW㫭n򥿬D)d݇r:p`aLIN|yl[n/X_*ox3@Է˼LZJ˶:*L|ޒ&ULπ)jp;|M)]e -OI~Tb3EE*owRTajM'=› HAmkL G7K wś>|콎|l26zh`],vG,1ws%CҖ !3*@u zFe= dN&Z.ۅoT!5YkeSF hpS)` =*cƅ>dqЋ'>vX.(/:mw|8!@D"n$B )|<+ Rʘ{^ sܼGG j5oӮJ :[`{Y/vz5f2 z4&dќVӑ>44- l9_iJk_#VUn"#(v #hxdܓÚ>Y"H0?B6>cۺ@,oXLa-VaQtqu#G.Pٜ4ʂ4xGԻäU5,Ppo}E3|`~V$J|Y䃲ކxC.C v5sQf:d r &4~l7j?Ԛou.ă괎"HkB|R"GMMuTXKd(&BR>~S=IC9J$MfUW/`\j*ll׀4ԽUq*s5XY?.~_ԽWg[im uDzVkXC5kV)> A O+PjKVׅY**lhQjaR!&`ӵ;2PcALSI*x6 6* `J(T6PY@%w6K>OaaSs NӁP0y>f=sX +cN(dHw cswW5yJB#*}@sӃX@r&LƋ Sja}<;~IqcգRTKU8Jv%3\ZV3֜ܲ"o"BEH/@1Cf"6M!pzz>X`m"'c|],U^Fl E*Uɚ߸* ߁F^%YYȵ9 :gM@e#3>k8)B+`_gGSāEeQalraܥD~<~ xă %I\YMjD`y<xDKa rqhMg'?8ԑ10=:_zB}`u+@#sd)aGY5\U,^c7T2) g(:[LQRmzH GNe KA{N4[]#O˴\WHGJU1wd S򒓁;"Qd1GMr! ,,5BmEKJ:3U2##l 0!is'"UO k(*,QAUJ:F%bބVRx. >vx2tTY8S 9[T$8 !|㿼6IL9=94U[.eE͇Aw}3M7 $'B9qj%;\J5Iyzv?a(o@M/agbQws ?^c=-s$4sԛ7)db! 5K(IRV` J,|zd(pPtLYklIyrm`p!QkJ6pLV}CkC䯞W!U4$ \ ̱+%VXRؕ5%Pg\P 騮 !H4rźu4rm#]SfW^quIŹL zk38:?ӐSTf76vAxvǪgb≞8Ra~b yRB7/v8W3_ %{F*ə9/A'՜eo-^ȁ^NCtgK;~rm'5!` Y•p᥸ZL婬nI+9YC/.՚k]H/@dҠ2_Pj RJ ܑn4HkuM1Ma3ɑ j-ɟm$ J.ϲy֥[fG`tʝ_$ڨ( f]7Y* 﫾l.r ?FH'W"VD4#yIfĸ&9L^t ^H|(%6HJTOD]Pali@Kz t54K6`xZ? ˡgifS:ȋN +U;P#gtd@Kش>f[L#J?Y<;˷1x G=FuKQ0n3Ao_x?4AtUukt-C7TU+R!1BgLDkg4 `@UT2O`} Z_INJr/R"xB!uHyÐ0d}GQ8xp0qCKW zV{Dbڿe$V\!<-HKhMVx.  h\+C'&ʚ~ >5<7 0N£t"xmt3NDoyus^8!t@PT!)Fc&]LS- .ޅ+B:6އ PAJoI0$fؽ+ -ylj+97gw[[ ýX4>dh8\=ƚډa2dyzt2]'#?S?gΨki5zT>v@rhg1 P J7[@K;Zফ%Y eR$y⡂mnwC ՃW,U/B>M,g8B}T-HhA64Dh nb)wJ3A&w?Cyo!+2:sQYey^DsOǢwZ1/h}w~cf㥁H#@= Y不NPk[}[tC[[bv}+f}G\Z`sh1lppYJ3n.]F \i w‹L| b5aE5%zAgY޷,9k$+S.L63ͶVCk5&Pğ0cldY~Џ;@6TP7dUY_ڥOkZՄy5$t+<$:k-R r/7{&>N!+LV?@-3lXF_|Rsq◎Uw2..:@65a#Njmwi‚,"$GB4 hz>͇#*e@ +欅;&=A9kW=7/GOB;5=u#i`3\{KPz3Ȳa 3gfzʱ}79raU0y:D-&iD|-NW@9nq]{W~9FR #]7fBX ]qG2}`4.}TDSXA&D(^D(Y}꺡UfW3M ry*8leN&L .6$Z^FQst\'^i9&ϓT'3P%r ! &!$e"= Xx$@D0:AO$ b 'ݠN}QVq$޿mhsApOgViie-ޯN8Cv Q)K9GM_nFN1 Qڨ5 b\CdRhL 7x#Wx8#qh)o-o!+D!)A^感"f;-/4z'V`*a9֜r_&:6_/Ż*/1IMf -=-ɘ: - d}t؊|SXTxs)$U[JnwPEh0]ET2(f $' =M" 6ʠsJ;WA ۂv蛠ˆ,_wdzﴱ)3haed2kKrς0OM#opdX+ W=$*duV[ۻ[u>3j(B_BwW՗c^qڐ wl3k]l6b"$G6_o8Qsv۸dU|P@pP¤4H[hR}(y[2J\BK]L[%?\RrRe3M )cGb8fa Kz&vwZA8CV}`9yǺra#A)@[vd'gȫ=_" ~ ZlhY=c@'v!d]wQ+> *jjo^թeSzVQVȪzGO m}, F| B!hb˷Ff xᮐ1feDnNP)cbg, L\:Cv9rgі1=^/,B>,밁;:M 2k{xB-Llr~cuƏ+?/LIE^h3oyVb&Bݜl&rVAfE7 b5؄5 l?ݲ\@Yu9d1]%^҂SCSCf3m}#) >Po{=qm1Ɇ @)[?fC-\GC$j6nsMb|a\c>VVtTHQ = ̋{ Ͽ˽sIm*^`!޲vVK\-H(˚X'QŹq_`󍸺٨4M+ a' *⩑_19W0Dt2b{wvq|mSh0TEWYН5^~,,򭱎hlz0Ńh> Ʊ=q0RL[T7Jٿ~⻻7~sI CfW0])Oi1u6&pi8x-.Bꭂ9U]E_V811C[ ?(3J/%,}fT5cR_u`_x endstream endobj 616 0 obj <> endobj 617 0 obj [618 0 R 619 0 R 620 0 R 621 0 R 622 0 R 623 0 R 624 0 R 625 0 R 626 0 R 627 0 R 628 0 R 629 0 R 630 0 R 631 0 R 632 0 R 633 0 R 634 0 R 635 0 R 636 0 R 637 0 R 638 0 R 639 0 R 640 0 R 641 0 R 642 0 R 643 0 R] endobj 618 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:93. Liu, C. H. etal. Nodal  spectrins are required to maintain Na+ cha\ nnel clustering and axon integrity. eLife 9, e52378 \(2020\).\r:365)/F 4/H/N/Rect[396.14 664.855 401.442 652.444]/Subtype/Link/Type/Annot>> endobj 619 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:104. Huang, C. Y., Zhang, C., Zollinger, D. R., Leterrier, C. \n& Rasband,\ M. N. An II spectrin-based cytoskeleton protects large-diameter myelinated axons from degeneration. J. Neurosci. 37, 1132\ 3 11334 \(2017\).\r:366)/F 4/H/N/Rect[472.901 653.855 480.883 641.444]/Subtype/Link/Type/Annot>> endobj 620 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:124. Yoshimura, T., Stevens, S. R., Leterrier, C., \nStankewich, M. C. & Rasband\ , M. N. Developmental changes in expression of IV spectrin splice variants at axon initial segments and nodes of Ranvier. Fro\ nt. Cell Neurosci. 10, 304 \(2017\).\r:367)/F 4/H/N/Rect[542.444 576.855 550.658 564.444]/Subtype/Link/Type/Annot>> endobj 621 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Fig. 4 | A model for glia-directed placement of axonal cytoskeletal scaffol\ ds and barriers. Axonal 2 and 4 spectrin occupy mutually exclusive domains \(parts a and d\), hence forming the basis f\ or the generation of non- overlapping dom:368)/F 4/H/N/Rect[370.487 444.855 378.572 432.444]/Subtype/Link/Type/Annot>> endobj 622 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Fig. 4 | A model for glia-directed placement of axonal cytoskeletal scaffo\ lds and barriers. Axonal 2 and 4 spectrin occupy mutually exclusive domains \(parts a and d\), hence forming the basis \ for the generation of non- overlapping do:369)/F 4/H/N/Rect[444.066 367.855 448.476 355.444]/Subtype/Link/Type/Annot>> endobj 623 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:38. Feinberg, K. etal. A glial signal consisting of gliomedin and \ NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier. Neuron 65, 490 502 \(2010\). \nThis paper sho\ ws that gliomedin and NrCAM function as th:370)/F 4/H/N/Rect[499.33 290.855 504.606 278.444]/Subtype/Link/Type/Annot>> endobj 624 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:39. Susuki, K. etal. Three mechanisms assemble central nervous sys\ tem nodes of Ranvier. Neuron 78, \n469 482 \(2013\). \nThis paper reveals perinodal NF186-interacting ECM molecules that func\ tion as a secondary mechanism after parano:371)/F 4/H/N/Rect[531.824 224.855 536.856 212.444]/Subtype/Link/Type/Annot>> endobj 625 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:48. Amor, V. etal. The paranodal cytoskeleton clusters Na+ channels \ at nodes of Ranvier. eLife 6, e21392 \(2017\). \nThis paper shows that, in the absence of NF186, the paranodal 2 spectrin-d\ ependent cytoskeleton clusters nodal Na:372)/F 4/H/N/Rect[455.738 136.855 461.03 124.444]/Subtype/Link/Type/Annot>> endobj 626 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Fig. 2 | Two overlapping axoglial adhesion systems assemble the nodes of R\ anvier. \na | The initial clustering of Na+ channels occurs at heminodes that flank each of the \nforming myelin segments\ and paranodal loops \(PNL\). This clusteri:373)/F 4/H/N/Rect[526.719 81.8547 531.129 69.4439]/Subtype/Link/Type/Annot>> endobj 627 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:112. Poliak, S. & Peles, E. The local differentiation of myelinated axons at n\ odes of Ranvier. Nat. Rev. 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Neurosci. \n26, 5230 5239 \(2006\).\r:354)/F 4/H/N/Rect[284.19 510.855 291.927 498.444]/Subtype/Link/Type/Annot>> endobj 634 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Table 1 | Adhesion, ECM and cytoskeletal components of the nodes of Ranvie\ r\r:355)/F 4/H/N/Rect[166.959 477.855 171.442 465.444]/Subtype/Link/Type/Annot>> endobj 635 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Fig. 1 | Organization of the nodal environ. a | Myelin form\ ed by Schwann cells or \noligodendrocytes \(not shown\) covers the axon in segments \(internodes\) separated by \nthe nodes of Ranv\ ier. The nodes of Ranvier, which are flanke:356)/F 4/H/N/Rect[190.294 477.855 198.218 465.444]/Subtype/Link/Type/Annot>> endobj 636 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:121. Chang, K. J. etal. Glial ankyrins facilitate paranodal axoglial junction\ assembly. Nat. Neurosci. 17, \n1673 1681 \(2014\).\r:357)/F 4/H/N/Rect[296.823 422.855 304.357 410.444]/Subtype/Link/Type/Annot>> endobj 637 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:122. Susuki, K. etal. Glial II spectrin contributes to paranode formation and\ maintenance. J. Neurosci. 38, 6063 6075 \(2018\).\r:358)/F 4/H/N/Rect[305.517 422.855 313.051 410.444]/Subtype/Link/Type/Annot>> endobj 638 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Fig. 1 | Organization of the nodal environ. a | Myelin for\ med by Schwann cells or \noligodendrocytes \(not shown\) covers the axon in segments \(internodes\) separated by \nthe nodes of Ran\ vier. The nodes of Ranvier, which are flank:359)/F 4/H/N/Rect[330.193 422.855 337.867 410.444]/Subtype/Link/Type/Annot>> endobj 639 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:123. Galiano, M. R. etal. A distal axonal cytoskeleton forms an intra-axonal b\ oundary that controls axon initial segment assembly. Cell 149, 1125 1139 \(2012\).\r:360)/F 4/H/N/Rect[264.21 378.855 272.059 366.444]/Subtype/Link/Type/Annot>> endobj 640 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:107. Zhang, C., Susuki, K., Zollinger, D. R., Dupree, J. L. \n& Rasband, M. N. \ Membrane domain organization \nof myelinated axons requires II spectrin. J. Cell Biol. 203, 437 443 \(2013\). \nThis paper \ demonstrates the molecular basis of the par:361)/F 4/H/N/Rect[183.826 290.855 191.426 278.444]/Subtype/Link/Type/Annot>> endobj 641 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:60. Brivio, V., Faivre-Sarrailh, C., Peles, E., Sherman, D. L. & Brophy, P. J.\ Assembly of CNS nodes of Ranvier in myelinated nerves is promoted by the axon cytoskeleton. Curr. Biol. 27, 1068 1073 \(201\ 7\). \nThis paper supports the role of the:362)/F 4/H/N/Rect[160.227 180.855 165.466 168.444]/Subtype/Link/Type/Annot>> endobj 642 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Fig. 4 | A model for glia-directed placement of axonal cytoskeletal scaffolds\ and barriers. Axonal 2 and 4 spectrin occupy mutually exclusive domains \(parts a and d\), hence forming the basis for\ the generation of non- overlapping domai:363)/F 4/H/N/Rect[232.858 59.8547 241.027 47.4439]/Subtype/Link/Type/Annot>> endobj 643 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Fig. 4 | A model for glia-directed placement of axonal cytoskeletal scaffold\ s and barriers. 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'#CٯY Mr4dA^lD3r>urc5G(*!̙,a S;?%N?ZffxGG֨gugǬ7gh }`8a[@p,v[i@(=8o9 EpyC: QW7Hc8mT h?:<^VP幖ZҏAWA$V`R߰tx,|X,D-I%99|>U"V'-3L?P%ľ HUR[6WgCgW2`bנ(cLǽ,@/ʴU !. 4at(*{[ַ!pFTnuΫ7Tu<]I$F7wܕ=w\(˷+_\_ V19>?S )ފA9iuvL{C'#p[t4ܬ21;t1•W~WCuc{;vj̛6Qˎb퓫 a!;6r˒t~)[Y(nsn]'- [L~S6  j{dly=7T* uN'q=+9t"_PåB"6L(n9uE aļ{~^Nx#:s}b|3nL dǹN^/";ddc||jG٣a"N<*$pڞdРB#Ŝ?'7v۠fP6|p M7)f"-HD,R?.#&%BxTB5SCVi8΁GX'=:/UszpwP||w}_Wo=[ͥʪXmz.?mbF`G 9mzW)xtxP X ;Qž/(EymD-M-(ڵ]Bͻ!+ŻfU˂`{sQy_k\tq#`ԋ5٬;u5 endstream endobj 646 0 obj <> endobj 647 0 obj [648 0 R 649 0 R 650 0 R 651 0 R 652 0 R 653 0 R 654 0 R 655 0 R] endobj 648 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:125. Seidl, A. H., Rubel, E. W. & Harris, D. M. Mechanisms for adjusting intera\ ural time differences to achieve binaural coincidence detection. J. Neurosci. 30, 70 80 \(2010\).\r:381)/F 4/H/N/Rect[411.459 59.8547 419.086 47.4439]/Subtype/Link/Type/Annot>> endobj 649 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:39. Susuki, K. etal. Three mechanisms assemble central nervous sy\ stem nodes of Ranvier. Neuron 78, \n469 482 \(2013\). \nThis paper reveals perinodal NF186-interacting ECM molecules that fun\ ction as a secondary mechanism after paran:374)/F 4/H/N/Rect[172.902 235.855 178.13 223.444]/Subtype/Link/Type/Annot>> endobj 650 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Fig. 4 | A model for glia-directed placement of axonal cytoskeletal scaff\ olds and barriers. Axonal 2 and 4 spectrin occupy mutually exclusive domains \(parts a and d\), hence forming the basis\ for the generation of non- overlapping d:375)/F 4/H/N/Rect[159.303 202.855 167.712 190.444]/Subtype/Link/Type/Annot>> endobj 651 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Fig. 4 | A model for glia-directed placement of axonal cytoskeletal scaf\ folds and barriers. Axonal 2 and 4 spectrin occupy mutually exclusive domains \(parts a and d\), hence forming the basi\ s for the generation of non- overlapping :376)/F 4/H/N/Rect[172.242 202.855 175.729 190.444]/Subtype/Link/Type/Annot>> endobj 652 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:37. Eshed, Y. etal. Gliomedin mediates schwann cell-axon interactio\ n and the molecular assembly of the nodes of ranvier. Neuron 47, 215 229 \(2005\). \nThis paper shows that gliomedin is the \ Schwann cell-derived factor that interacts:377)/F 4/H/N/Rect[336.548 180.855 341.858 168.444]/Subtype/Link/Type/Annot>> endobj 653 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Fig. 4 | A model for glia-directed placement of axonal cytoskeletal sca\ ffolds and barriers. Axonal 2 and 4 spectrin occupy mutually exclusive domains \(parts a and d\), hence forming the bas\ is for the generation of non- overlapping:378)/F 4/H/N/Rect[159.544 169.855 168.403 157.444]/Subtype/Link/Type/Annot>> endobj 654 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:Fig. 4 | A model for glia-directed placement of axonal cytoskeletal sc\ affolds and barriers. Axonal 2 and 4 spectrin occupy mutually exclusive domains \(parts a and d\), hence forming the ba\ sis for the generation of non- overlappin:379)/F 4/H/N/Rect[172.961 169.855 175.182 157.444]/Subtype/Link/Type/Annot>> endobj 655 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:39. Susuki, K. etal. Three mechanisms assemble central nervous s\ ystem nodes of Ranvier. 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Grubb, M. S. & Burrone, J. Activity-dependent relocation of the axon initi\ al segment fine-tunes neuronal excitability. Nature 465, 1070 1074 \(2010\).\r:382)/F 4/H/N/Rect[289.085 708.855 296.815 696.444]/Subtype/Link/Type/Annot>> endobj 688 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:127. Kuba, H., Oichi, Y. & Ohmori, H. Presynaptic activity regulates Na+ chan\ nel distribution at the axon initial segment. Nature 465, 1075 1078 \(2010\).\r:383)/F 4/H/N/Rect[298.04 708.855 305.771 696.444]/Subtype/Link/Type/Annot>> endobj 689 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:128. Dutta, D. J. etal. Regulation of myelin structure \nand conduction velocit\ y by perinodal astrocytes. \nProc. Natl Acad. Sci. USA 115, 11832 11837 \(2018\).\r:384)/F 4/H/N/Rect[249.184 631.855 257.095 619.444]/Subtype/Link/Type/Annot>> endobj 690 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:129. Arancibia-Carcamo, I. L. etal. Node of Ranvier length as a potential regu\ lator of myelinated axon conduction speed. eLife 6, e23329 \(2017\).\r:385)/F 4/H/N/Rect[199.28 609.855 206.882 597.444]/Subtype/Link/Type/Annot>> endobj 691 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:130. Orthmann-Murphy, J. etal. Remyelination alters \nthe pattern of myelin in \ the cerebral cortex. eLife 9, e56621 \(2020\).\r:386)/F 4/H/N/Rect[222.121 554.855 229.979 542.444]/Subtype/Link/Type/Annot>> endobj 692 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:6. Boiko, T. etal. Compact myelin dictates the differential targeting of two\ sodium channel isoforms in the same axon. Neuron 30, 91 104 \(2001\).\r:387)/F 4/H/N/Rect[223.19 488.855 225.772 476.444]/Subtype/Link/Type/Annot>> endobj 693 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:131. Moldovan, M. etal. Aging-associated changes in motor axon voltage-gated N\ a+ channel function \nin mice. Neurobiol. Aging 39, 128 139 \(2016\).\r:388)/F 4/H/N/Rect[225.399 466.855 233.042 454.444]/Subtype/Link/Type/Annot>> endobj 694 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:12. Devaux, J. etal. Kv3.1b is a novel component \nof CNS nodes. J. Neurosci\ . 23, 4509 4518 \n\(2003\).\r:389)/F 4/H/N/Rect[320.559 455.855 325.749 443.444]/Subtype/Link/Type/Annot>> endobj 695 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:132. Devaux, J. J. & Scherer, S. S. Altered ion channels \nin an animal model of\ Charcot-Marie-Tooth disease type IA. J. Neurosci. 25, 1470 1480 \(2005\).\r:390)/F 4/H/N/Rect[189.443 422.855 197.252 410.444]/Subtype/Link/Type/Annot>> endobj 696 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:39. Susuki, K. etal. Three mechanisms assemble central nervous \ system nodes of Ranvier. Neuron 78, \n469 482 \(2013\). \nThis paper reveals perinodal NF186-interacting ECM molecules that f\ unction as a secondary mechanism after par:391)/F 4/H/N/Rect[266.009 334.855 271.104 322.444]/Subtype/Link/Type/Annot>> endobj 697 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:56. Dzhashiashvili, Y. etal. Nodes of Ranvier and axon initial segments are \ ankyrin G-dependent domains that assemble by distinct mechanisms. J. Cell Biol. 177, 857 870 \(2007\). \nThis paper shows th\ at assembly of nodes of Ranvier depends on:392)/F 4/H/N/Rect[272.3 334.855 277.396 322.444]/Subtype/Link/Type/Annot>> endobj 698 0 obj <>/BS<>/Border[0 0 0]/Dest(SpringerNature_NatRevNeuroSci_406.indd:133. Auer, F., Vagionitis, S. & Czopka, T. Evidence for myelin sheath remodelin\ g in the CNS revealed by invivo imaging. Curr. 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Rasband Elior Peles 10.1038/s41583-020-00406-8 http://dx.doi.org/10.1038/s41583-020-00406-8 journal Nature Reviews Neuroscience © 2020, Springer Nature Limited 1471-0048 10.1038/s41583-020-00406-8 springer.com springerlink.com 2010-04-23 True 10.1038/s41583-020-00406-8 springer.com springerlink.com Springer 2020-12-09T12:47:46+05:30 2020-12-09T12:46:52+05:30 2020-12-09T12:47:46+05:30 True VoR uuid:db1efd3d-a321-48dd-87fb-6242afb1a7e7 uuid:1d063699-5472-4c45-8e42-501e9fc4c53f default 1 converted uuid:1332a927-b993-4a11-a00e-48b3dae6397e converted to PDF/A-2b pdfToolbox 2020-12-09T12:47:46+05:30 2 B Matthew N. Rasband http://orcid.org/0000-0001-8184-2477 Elior Peles http://orcid.org/0000-0002-3325-0597 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. 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